Early detection of gallbladder cancer: Current status and future perspectives

Table 7 Major studies on association of various serological markers in gall bladder cancer

Serial number	Biological markers	Cut off value	Sensitivity	Specificity	Ref.
1	CEA	5 ng/mL	52%	55%	[115]
	CA19-9	37 U/mL	74%	82%
	CYFRA 21-1	2.7 ng/mL	76%	79%
	MMP7	7.5 ng/mL	78%	77%
	Combination of all four	-	92%	96%
2	CEA	1.95 ng/mL	90.2%	35.29%	[116]
	CA19-9	26 U/mL	58.82%	83.82%
	Combination of the two	-	90.2%	88.24%
3	CEA	10 μg/L	11.5%	97.4%	[117]
	CA19-9	39 U/mL	71.7%	96.1%
	CA242	15 U/mL	64.1%	98.7%
	CA125	35 U/mL	44.8%	96.2%
4	CA 242	20 U/mL	64%	84%	[118]
	CEA	5 U/mL	61%	44%
	CA 19–9	35 U/mL	17%	67%
5	CYFRA 21-1	3.27 ng/mL	93.7%	96.2%	[119]
	CYFRA 21-1	2.61 ng/mL	74.6%	84.6%
	CYFRA 21-1	3.27 ng/mL	75.6%	96.2%
	CYFRA 21-1	2.27 ng/mL	71.0%	71.2 %
6	CA 19-9	39 U/mL	71.3%	90.0%	[120]
	CA 125	36 U/mL	38.8%	93.3%
	CEA	10.36 U/mL	12.5%	92.5%
	CA 242	15 U/mL	86.3%	90.0%
7	CA 19-9	252.31 U/mL	100%	98.90%	[121]
	CA 125	92.19 U/mL	100%	94.50%
8	CA 19-9	250 U/mL	76.3%	70.8%	[122]

CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; CYFRA 21-1: Cytokeratin-19 fragment antigen 21-1; MMP7: Matrix metalloproteinase-7.