Swollen lymph node metastasis and survival in gastric cancer: Multi-institutional post-resection analysis

Table 2 The univariate and multivariate survival analyses of patients with gastric cancer

Variables	n	5-year overall survival (%)	Univariate analysis		Multivariate analysis
			χ² value	P value	Hazard ratio (95%CI)	P value
Sex			2.743	0.098
Male	359	27.1
Female	148	36.1
Age (years)			10.663	0.001
< 70	354	33.7			1 (Reference)
≥ 70	153	20.4			1.478 (1.178-1.856)	0.001
Preoperative tumor marker			13.180	< 0.001
Normal	387	33.5			1 (Reference)
Elevated	120	17.4			1.339 (1.046-1.713)	0.020
Tumor location			31.899	< 0.001
Lower one-third	172	37.6			1 (Reference)
Middle one-third	74	30.6			1.412 (0.977-2.040)	0.066
Upper one-third	167	29.0			1.443 (1.091-1.909)	0.010
2/3 or more	94	16.7			1.543 (1.090-2.182)	0.014
Tumor size			17.164	< 0.001
< 5 cm	186	40.0			1 (Reference)
≥ 5 cm	321	23.7			1.248 (0.992-1.569)	0.058
Borrmann type			17.506	< 0.001
I, II	188	38.3			1 (Reference)
III, IV	319	24.5			1.352 (1.070-1.707)	0.011
Histology			7.512	0.006
Differentiated	147	38.4			1 (Reference)
Undifferentiated	360	26.2			1.156 (0.904-1.480)	0.248
Depth of invasion
T1	18	88.5	81.327	< 0.001	1 (Reference)
T2	31	79.5			1.480 (0.377-5.815)	0.575
T3	60	45.7			4.344 (1.313-14.367)	0.016
T4a	367	21.4			7.788 (2.440-24.855)	0.001
T4b	31	12.1			9.456 (2.779-32.171)	< 0.001
N stage			77.324	< 0.001
N1	149	48.2			1 (Reference)
N2	174	32.5			1.448 (1.061-1.976)	0.020
N3	184	11.9			1.624 (1.206-2.187)	0.001
Tumor deposits			9.634	0.002
Negative	376	31.7			1 (Reference)
Positive	131	24.1			1.279 (0.999-1.637)	0.051
Lymphovascular invasion			12.039	< 0.001
Negative	377	34.2			1 (Reference)
Positive	130	16.4			1.356 (10.68-1.722)	0.012
Type of gastrectomy			7.213	0.007
Subtotal	325	32.4			1 (Reference)
Total	182	25.0			1.018 (0.789-1.314)	0.890
Swollen lymph node metastasis			45.585	< 0.001
Absent	368	35.8			1 (Reference)
Present	139	13.6			1.318 (1.026-1.695)	0.031

Ref: Reference.