NOTCH1 combined with chemotherapy synergistically inhibits triple-negative breast cancer

Figure 3 NOTCH1 and NT5E are positively correlated in triple-negative breast cancer cells. A and B: Western blot and RT-PCR results show that NT5E protein and mRNA levels are downregulated in stable NOTCH1-knockdown MDA-MB-231 cells; C and D: Online database prediction indicated a positive correlation between the mRNA expression levels of NOTCH1 and NT5E in breast cancer; E: In the 101 triple-negative breast cancer patients in The Cancer Genome Atlas, the mRNA expression levels of NOTCH1 and NT5E were positively correlated.; F-I: Online database prediction suggesting that low expression of NOTCH1 or NT5E was associated with better overall survival and disease-free survival in patients. ^aP < 0.05; ^bP < 0.01.