Case Control Study
Copyright ©The Author(s) 2025.
World J Clin Oncol. May 24, 2025; 16(5): 106409
Published online May 24, 2025. doi: 10.5306/wjco.v16.i5.106409
Table 5 Prevalence of advanced colorectal neoplasia by risk tier, n (%)
Risk tier (risk score)Derivation cohort
Validation cohort
Validation cohort (male)
Validation cohort (female)
Number of subjects
ACN
Number of subjects
ACN
Relative risk (95%CI)
Number of subjects
ACN
Relative risk (95%CI)
Number of subjects
Advanced colorectal neoplasia
Relative risk (95%CI)
Low risk (0–2)1938 (42.2)63 (3.3)943 (49.9)47 (5.0)1 (Reference)356 (34.4)16 (4.5)1 (Reference)587 (68.6)31 (5.3)1 (Reference)
Moderate risk (3–4)1983 (43.2)185 (9.3)727 (38.4)75 (10.3)2.07 (1.46-2.94)489 (47.2)42 (8.6)1.91 (1.09-3.34)238 (27.8)33 (13.9)2.62 (1.65-4.18)
High risk (5–7)671 (14.6)124 (18.5)221 (11.7)39 (17.6)3.55 (2.38-5.26)190 (18.4)32 (16.8)3.75 (2.11-6.67)31 (3.6)7 (22.6)4.27 (2.05-8.93)
Total4592372 (8.1)1891161 (8.5)1035 (54.7)90 (8.7)856 (45.3)71 (8.3)