Case Control Study
Copyright ©The Author(s) 2025.
World J Clin Oncol. May 24, 2025; 16(5): 106409
Published online May 24, 2025. doi: 10.5306/wjco.v16.i5.106409
Table 1 Characteristics of the derivation and validation cohorts, n (%)

Derivation cohort (n = 4592)
Validation cohort (n = 1891)
P value
Age (years), mean ± SD45.8 ± 12.447.1 ± 12.40.000
Sex, male2458 (53.5)1035 (54.7)0.381
Regular excise2090 (45.6)670 (35.4)0.000
Smoking809 (17.6)378 (20.0)0.029
Alcohol consumption606 (13.2)352 (18.6)0.000
Use of non-steroidal anti-inflammatory drugs105 (2.3)89 (4.7)0.000
Hypertension542 (11.8)276 (14.6)0.003
Diabetes mellitus222 (4.9)104 (5.5)0.289
Hyperlipemia410 (8.9)266 (14.1)0.000
Colorectal cancer family history347 (7.6)136 (7.2)0.640
Post-cholecystectomy 130 (2.9)34 (1.8)0.015
Rectal bleeding199 (4.3)90 (4.8)0.499
Change of bowel habit275 (6.0)120 (6.3)0.585
Abdominal pain731 (15.9)354 (18.7)0.105
Body mess index (kg/m2), mean ± SD23.3 ± 3.323.4 ± 3.30.264
Waist circumference (cm), mean ± SD82.5 ± 10.383.4 ± 10.80.003
Waist-hip ratio, mean ± SD0.885 ± 0.790.891 ± 0.890.014
Normal/diverticulum/colitis/neuroendocrine neoplasms/hyperplastic polyps3124 (68.0)1241 (65.6)0.061
Advanced colorectal neoplasia372 (8.1)161 (8.5)0.582
Cancer58 (1.3)20 (1.1)0.490