Natural compound rosmarinic acid displays anti-tumor activity in colorectal cancer cells by suppressing nuclear factor-kappa B signaling

Figure 5 Rosmarinic acid enhances chemotherapeutical effects in colorectal cancer cells. A and B: HT29 (A) and SW480 (B) cells were incubated with 2.5 μg/mL 5-fluorouracil and/or 50 μg/mL rosmarinic acid for 48 hours, followed by Cell Counting Kit-8 assay; C and D: HT29 (C) and SW480 (D) cells were incubated with 10 μM oxaliplatin and/or 50 μg/mL rosmarinic acid for 48 hours, followed by Cell Counting Kit-8 assay. n = 3. Data are shown as the mean ± SD. ^aP < 0.001, ^bP < 0.0001. RA: Rosmarinic acid; OXA: Oxaliplatin. 5-FU: 5-fluorouracil.