Systematic Reviews
Copyright ©The Author(s) 2022.
World J Clin Oncol. Nov 24, 2022; 13(11): 929-942
Published online Nov 24, 2022. doi: 10.5306/wjco.v13.i11.929
Table 2 Characteristics of included studies exploring link between gut microbiome composition and diversity and response to immune-checkpoint blockade therapy in metastatic melanoma patients treated with immune-checkpoint blockade therapy
Ref.
Year
Therapy
Method
Sample size/ time point
Dominant microbes
Microbial diversity
Chaput et al[27], 2017 2017Anti-CTLA-416S rRNA gene sequencing of fecal samples 26 before txResponders: Faecalibacterium and FirmicutesN/A
Matson et al[29], 2018 2018Anti-PD-1 or anti-CTLA-416S rRNA gene and shotgun metagenome sequencing of fecal samples; qPCR on selected bacteria42 before txResponders: Bifidobacterium longum, Collinsella aerofaciens, and Enterococcus faecium Non-responders: Ruminococcus obeum and Roseburia intestinalisN/A
Gopalakrishnan et al[12], 20182018Anti-PD-116S rRNA gene and shotgun metagenome sequencing of fecal samples43 before txResponders: Clostridiales, in particular Faecalibacterium Non-responders: Bacteroidales, in particular Bacteroides thetaiotaomicron; as well as Escherichia coli, and Anaerotruncus colihominisHigher alpha diversity in patients with longer PFS
Peters et al[30], 20192019Anti-PD-1 or anti-CTLA-416S rRNA gene and shotgun metagenome sequencing of fecal samples 27 before txResponders: Faecalibacterium, Parabacteroides, and Faecalibacterium prausnitzii Non-responders: Bacteroides and Biophilia Higher microbial community richness and diversity was associated with longer PFS
Wind et al[31], 2020 2020Anti-PD-1 or anti-CTLA-4Shotgun metagenome sequencing of fecal samples25 before txResponders: Ruminococcus gnavus, Streptococcus parasanguinis, and Bacteroides massiliensis. Non-responders: Bifidobacterium longum and Peptostreptococcaceae No significant difference in alpha-diversity between responder and non responders
Baruch et al[26], 20202020Anti-PD-1 refractory16S rRNA gene and shotgun metagenome sequencing of fecal samples 10 anti-PD-1 refractory patientsFMT donors (responders): Lachnospiraceae, Veillonellaceae, and Ruminococcaceae Post FMT Responders: Enterococcaceae, Enterococcus, and Streptococcus australis Non-responders: Veillonella atypicaNo significant difference in GM composition prior to FMT, but significant difference post-FMT between responders and non-responders Lower microbial richness in the donor of responding recipients
Davar et al[28].2021 2021Anti-PD-1 refractoryShotgun metagenomic sequencing of fecal samples15 anti-PD-1 refractory patients, before FMTResponders: Firmicutes (Lachnospiraceae and Ruminococcaceae families) and Actinobacteria (Bifidobacteriaceae and Coriobacteriaceae families)Higher GM diversity of donors who were complete responders compared to donors who were partial responders No significant difference in GM diversity between donors and recipients prior to FMT
Andrews et al[36], 20212021Combined ICB - Anti-PD-1 and anti-CTLA-416S rRNA gene and shotgun metagenome sequencing of fecal samples 38Responders: Bacteroides stercoris, Parabacteroides distasonis, Fournierella massiliensis. Non-responders: Klebsiella aerogenes and Lactobacillus rogosaeNo significant difference in GM diversity between responders and non-responders