Neutrophil-to-lymphocyte ratio as a prognostic factor for survival in patients with colorectal liver metastases: A systematic review

Table 6 Univariate and multivariate analysis outcomes for patients treated with radio-frequency ablation, radioembolization or solely chemotherapy

Ref.	Univariate analysis	Multivariate analysis
Tohme et al[29]	High NLR associated with decreased OS P < 0.001	High NLR associated with decreased OS (HR = 1.927, 95%CI: 1.202-3.089, P = 0.006)
Chang et al[26]	Preoperative high NLR and postoperative increase in NLR were associated with decreased DFS (P = 0.044 and P = 0.022, respectively)	Only postoperative NLR increase was associated with decreased DFS (P = 0.029)
Zhang et al[27]	High NLR associated with decreased OS (P = 0.007) and DFS (P = 0.007)	High NLR associated with decreased OS (P = 0.039, HR = 3.59, 95%CI: 1.54-9.67) and DFS (P = 0.022, HR = 3.19, 95%CI: 1.87-8.24).
Weiner et al[28]	High NLR associated with decreased OS (HR = 2.18, 95%CI: 1.45-3.28, P = 0.0002)	High NLR associated with decreased OS (HR = 2.22, 95%CI: 1.46-3.38, P = 0.0002)
Kishi et al[15]	High NLR associated with decreased OS (HR = 3.1, 95%CI: 1.7-5.9, P < 0.001)	High NLR associated with decreased OS (HR = 2.9, 95%CI: 1.5-5.5, P = 0.001).
Wu et al[31]	High NLR (HR = 3.182, 95%CI: 1.277-7.933, P = 0.013) associated with decreased OS and DFS (HR = 2.284, 95%CI: 1.156-4.498, P = 0.017). Patients with normalization of NLR had better DFS than those with high NLR that did not decrease (P = 0.002).	No association between NLR and survival
Philips et al[30]	High NLR associated with decreased OS P = 0.067 (statistically significant)	No association between NLR and survival

CI: Confidence interval; RFA: Radio-frequency ablation; RE: Radioembolization; OS: Overall survival; DFS: Disease-free survival; NLR: Neutrophil to lymphocyte ratio.