Tumor-specific lytic path “hyperploid progression mediated death”: Resolving side effects through targeting retinoblastoma or p53 mutant

Figure 2 Structural analysis of human retinoblastoma protein. A: 3D structure of the inactive retinoblastoma protein pocket domain of retinoblastoma-1 (PDB ID: 4ELL). The model was generated using PyMol molecular graphics system, version 1.2r3pre, Schrödinger, LLC. B: Structures (or structural model) of phosphorylated retinoblastoma. The model shows the protein dimer as observed in the asymmetric crystal unit for retinoblastoma^PL–P. The structural coordinates for PDB ID 4ELL were downloaded from the NIH protein database. PyMol was used to re-enter the image of the model as shown. Rb: Retinoblastoma.