Impact of conditioning regimen on peripheral blood hematopoietic cell transplant

Table 4 Multivariable analysis shows no association of cell doses with overall survival or progression free survival, except for total nucleated cell dose in the reduced intensity conditioning + total body irradiation group

Variable	Overall survival1					Progression free survival2
	All patients (n = 247)	MA-noTBI (n = 38)	MA + TBI (n = 51)	RIC-noTBI (n = 118)	RIC + TBI (n = 40)	All patients (n = 247)	MA-noTBI (n = 38)	MA + TBI (n = 51)	RIC-noTBI (n = 118)	RIC + TBI (n = 40)
CD3+ cell dose
< Median HR	1	1	1	1	1	1	1	1	1	1
> Median HR	1.1	1.0	0.5	1.3	0.8	1.0	1.1	0.4	1.4	0.6
95%CI	0.8-1.5	0.4-2.6	0.2-1.1	0.8-2.1	0.3-2.2	0.7-1.4	0.4-2.6	0.2-1.0	0.8-2.2	0.2-1.7
P	NS	NS	NS	NS	NS	NS	NS	0.05	NS	NS
CD4+ cell dose
< Median HR	1	1	1	1	1	1	1	1	1	1
> Median HR	1.2	1.1	0.6	1.2	2.0	1.1	1.1	0.5	0.3	1.5
95%CI	0.8-1.7	0.4-2.6	0.2-1.3	0.8-1.0	0.7-6.0	0.8-1.6	0.5-2.6	0.2-1.2	0.8-2.1	0.5-4.3
P	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
CD8+ cell dose
< Median HR	1	1	1	1	1	1	1	1	1	1
> Median HR	1.2	1.5	1.0	1.3	0.5	1.1	1.1	0.9	1.2	0.7
95%CI	0.8-1.6	0.5-4.2	0.4-2.3	0.8-2.1	0.2-1.8	0.8-1.5	0.5-2.8	0.4-2.0	0.8-2.0	0.2-2.0
P	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
TNC dose
< Median HR	1	1	1	1	1	1	1	1	1	1
> Median HR	0.8	1.0	0.7	0.9	0.2	0.8	1.1	0.7	1.1	0.2
95%CI	0.6-1.2	0.4-2.4	0.3-1.9	0.5-1.5	0.1-0.8	0.6-1.2	0.4-2.5	0.3-1.6	0.6-1.8	0.1-0.8
P	NS	NS	NS	NS	0.02	NS	NS	NS	NS	0.02
CD34+ cell dose
< 4 × 106/kg HR	1	1	1	1	1	1	1	1	1	1
4-8 × 106/kg HR	1.0	0.5	1.3	1.1	0.6	0.8	0.7	1.2	1.0	0.6
95%CI	0.6-1.5	0.2-1.4	0.4-4.4	0.6-1.9	0.1-2.3	0.6-1.4	0.2-2.1	0.4-4.0	0.6-1.8	0.2-2.6
P	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
> 8 × 106/kg HR	1.0	1.3	0.7	1.1	0.5	0.9	1.5	0.6	1.1	0.5
95%CI	0.6-1.5	0.4-4.0	0.2-2.3	0.5-2.0	0.1-2.4	0.6-1.4	0.5-4.6	0.2-2.0	0.6-2.0	0.1-2.6
P	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS

¹Adjusted for age, KPS and BMI;

²Adjusted for KPS and BMI. KPS: Karnofsky performance score; BMI: Body mass index; HR: Hazard ratio; 95%CI: 95% confidence interval; MA: Myeloablative; TBI: Total body irradiation; RIC: Reduced intensity conditioning; NS: Not significant (P > 0.05).