Stereotactic body radiation therapy for non-small cell lung cancer: A review

Table 2 Toxicity results

Study	Grade 3 + toxicity	Reported adverse events
Miyakawa et al[20], 2017	Grade 3-5, 5.6%	Radiation pneumonitis
Sun et al[80], 2017	Grade 3, 5%	Dermatitis, radiation pneumonitis, chest wall pain
Singh et al[22], 2017, I-124407	Grade 3, 30%	NA
Bezjak et al[24], 2016, RTOG 0813	Grade 3-5, 16%-21%	Respiratory and cardiac toxicities, esophageal perforation, pulmonary hemorrhage
Navarro-Martin et al[11], 2016	Grade 3, 10%	Cough, dyspnea, dermatitis
Nyman et al[14], 2016, SPACE	Grade 3, 14%	Dyspnea, cough, skin reactions
Chang et al[15], 2015, STARS and ROSEL	Grade 3, 10%	Chest wall pain, cough, fatigue, rib fracture
Lindberg et al[19], 2015	Grade 3-4, 30%	Rib fracture, dyspnea, ventricle tachycardia, cough, fatigue, fibrosis, lung infection, pain, pericardial effusion
		Inop: Dyspnea, hypoxia, pneumonitis, chest pain, cough
Nagata et al[12], 2015, JCOG 0403	Grade 3-4, 13% (inop) Grade 3, 6% (op)	Op: Dyspnea, hypoxia, pneumonitis, chest pain
Shibamoto et al[6], 2015	Grade 3, < 10%	Radiation pneumonitis, pleural effusion, esophagitis, rib fracture, dermatitis
Videtic et al[13], 2015, RTOG 0915	Grade 3-5, 12%	DLCO changes, pneumonitis, PFT changes, 2 treatment-related deaths
Timmerman et al[18], 2014, RTOG 0236	Grade 3-4, 31%	Hypocalcemia, hypoxia, pneumonitis, PFT decreased
Taremi et al[26], 2012	Grade 3, 11%	Fatigue, cough, chest wall pain, rib fracture
Bral et al[46], 2011	Grade 3, 20%	Pneumonitis, cough
Ricardi et al[16], 2010	Grade 3-4, 3%	Radiation pneumonitis
Fakiris et al[17], 2009	Grade 3-5, 16%	Apnea, pneumonia, pleural effusion, hemoptysis, respiratory failure, skin erythema
Koto et al[10], 2007	Grade 3, 3%	Pneumonitis
McGarry et al[7], 2005	Grade 3-4, 15%	Pneumonitis, hypoxia, dermatitis, pericardial effusion, tracheal necrosis
Nagata et al[8], 2005	None	None

RTOG: Radiation therapy oncology group; JCOG: Japan clinical oncology group; Inop: Medically inoperable; Op: Medically operable; DLCO: Diffusing capacity of the lungs for carbon monoxide; PFT: Pulmonary function test.