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World J Clin Oncol. Jan 10, 2019; 10(1): 14-27
Published online Jan 10, 2019. doi: 10.5306/wjco.v10.i1.14
Stereotactic body radiation therapy for non-small cell lung cancer: A review
Kavitha M Prezzano, Sung Jun Ma, Gregory M Hermann, Charlotte I Rivers, Jorge A Gomez-Suescun, Anurag K Singh
Kavitha M Prezzano, Sung Jun Ma, Gregory M Hermann, Charlotte I Rivers, Jorge A Gomez-Suescun, Anurag K Singh, University at Buffalo, the State University of New York, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY 14214, United States
Kavitha M Prezzano, Sung Jun Ma, Gregory M Hermann, Charlotte I Rivers, Jorge A Gomez-Suescun, Anurag K Singh, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States
Author contributions: Prezzano KM and Ma SJ completed the literature review and compiled the tables; Prezzano KM, Ma SJ, Hermann GM and Rivers CI drafted the manuscript and contributed to analysis; Singh AK and Gomez-Suescun JA developed the concept and led the editing process; all authors contributed to data interpretation, editing the manuscript, and approval of the final version.
Conflict-of-interest statement: There are no conflicts of interest for any of the above authors.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Anurag K Singh, MD, Professor, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm St., Buffalo, NY 14263, United States. anurag.singh@roswellpark.org
Telephone: +1-716-8455715 Fax: +1-716-8457616
Received: September 25, 2018
Peer-review started: September 25, 2018
First decision: October 16, 2018
Revised: November 29, 2018
Accepted: December 17, 2018
Article in press: December 17, 2018
Published online: January 10, 2019
Core Tip

Core tip: Stereotactic body radiation therapy (SBRT) offers excellent local and regional control for early stage non-small cell lung cancer (NSCLC), and is often the treatment of choice for medically inoperable patients. This literature review provides an updated analysis of prospective clinical trials evaluating clinical outcomes following SBRT for early stage NSCLC.