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World J Clin Oncol. Aug 10, 2014; 5(3): 197-223
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.197
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.197
Paraneoplastic syndromes associated with lung cancer
Nobuhiro Kanaji, Naoki Watanabe, Nobuyuki Kita, Shuji Bandoh, Akira Tadokoro, Tomoya Ishii, Hiroaki Dobashi, Takuya Matsunaga, Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan
Author contributions: Kanaji N, Watanabe N, Kita N, Bandoh S, Tadokoro A, Ishii T, Dobashi H and Matsunaga T designed the study, searched and acquired the literature and drafted and revised the manuscript.
Correspondence to: Nobuhiro Kanaji, MD, PhD, Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. kanaji@med.kagawa-u.ac.jp
Telephone: +81-87-8912145 Fax: +81-87-8912147
Received: December 27, 2013
Revised: April 12, 2014
Accepted: May 29, 2014
Published online: August 10, 2014
Revised: April 12, 2014
Accepted: May 29, 2014
Published online: August 10, 2014
Core Tip
Core tip: A wide variety of paraneoplastic syndromes are associated with lung cancer, including endocrine, neurologic, dermatologic, rheumatologic, hematologic, and ophthalmological syndromes, as well as glomerulopathy and coagulopathy (Trousseau’s syndrome). The histological type of lung cancer is generally dependent on the associated syndrome, the two most common of which are humoral hypercalcemia of malignancy in squamous cell carcinoma and the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer. The symptoms of paraneoplastic syndromes often precede the diagnosis of lung cancer. The early detection and treatment of the underlying lung cancer offers the best outcomes for paraneoplastic syndromes.