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World J Clin Oncol. Aug 24, 2021; 12(8): 646-655
Published online Aug 24, 2021. doi: 10.5306/wjco.v12.i8.646
TRIM25: A central factor in breast cancer
Angeles C Tecalco-Cruz, María Jazmin Abraham-Juárez, Helena Solleiro-Villavicencio, Josué Orlando Ramírez-Jarquín
Angeles C Tecalco-Cruz, Helena Solleiro-Villavicencio, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), Mexico 03100, Mexico
María Jazmin Abraham-Juárez, Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Irapuato 36821, Mexico
Josué Orlando Ramírez-Jarquín, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico 04510, Mexico
Author contributions: Tecalco-Cruz AC planned the study, participated in the research, organization of this article, and wrote the manuscript; Abraham–Juárez MJ, Solleiro–Villavicencio H and Ramírez-Jarquín JO participated in the research, wrote some part of the manuscript, and prepared some figures of this article.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Angeles C Tecalco-Cruz, PhD, Full Professor, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), Colonia Del valle, San Lorenzo 290, Mexico 03100, Mexico. angeles.tecalco@uacm.edu.mx
Received: February 1, 2021
Peer-review started: February 1, 2021
First decision: March 31, 2021
Revised: April 2, 2021
Accepted: July 27, 2021
Article in press: July 27, 2021
Published online: August 24, 2021
Core Tip

Core Tip: TRIM25 is an E3-ligase enzyme for the ubiquitination and ISGylation system. TRIM25 expression is deregulated in breast cancer. The activity of TRIM25 is associated with changes in the proteome of mammary tumors. The molecular mechanisms of modulation and action of TRIM25 are implicated in breast cancer progression.