Strategies for overcoming anti-tumor necrosis factor drug antibodies in inflammatory bowel disease: Case series and review of literature

Table 2 A total of twelve patients on either infliximab or adalimumab were included in the case serie

Patient	Age (yr)	Sex	Diagnosis	Montreal classification	Duration of disease (yr)	Previous anti-TNF therapy?	Immunomodulator therapy?
1	24	M	CD	A2L3B1	5	Y	Previous - MTX
2	46	M	UC	E3	10	N	Previous - 6MP
3	71	M	CD	A3L1B2	4	N	Previous - 6MP
4	31	F	CD	A2L1B2	9	Y	Current - 6MP
5	46	F	CD	A2L3B2p	5	N	None
6	41	M	UC	E2	18	N	Current - AZA
7	53	F	UC	E2	24	Y	Previous - MTX
8	21	M	UC	E3	1	N	Current - MTX
9	67	M	CD	A3L2B1	3	N	None
10	26	M	CD	A1L2B1	11	N	None
11	49	F	CD	A2L3B2	30	N	None
12	25	M	CD	A2L1B2	7	Y	Current - MTX

Montreal classification CD: Age at Diagnosis (A1: Less than 16 years; A2: Between 17 and 40 years; A3: Over 40 years). Location (L1: Ileal; L2: Colonic; L3: Ileocolonic; L4: Isolated upper digestive tract). Behavior (B1: Non-stricturing, non-penetrating; B2: Structuring; B3: Penetrating; p: Perianal). Montreal classification UC: Location (E1: Proctitis; E2: Left-sided; E3: Extensive or pancolitis). M: Male; F: Female; CD: Crohn’s disease; UC: Ulcerative colitis; MTX: Methotrexate; 6-MP: 6-mercaptopurine; AZA: Azathioprine; TNF: Tumor necrosis factor.