Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity

doi:10.4292/wjgpt.v8.i1.26

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastrointest Pharmacol Ther. Feb 6, 2017; 8(1): 26-38
Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.26

Table 1 Psychotropic drugs with extensive first-pass metabolism[10-16]

Tricyclic antidepressants - first-pass metabolism greater than 50% after oral administration

SNRI antidepressants - venlafaxine

SSRI antidepressants - sertraline

NRI antidepressants - bupropion

Typical antipsychotics - chloropromazine

Atypical antipsychotics - olanzapine (40%), quetiapine

SSRI: Selective serotonin reuptake inhibitors; SNRI: Serotonin and norepinephrine reuptake inhibitors; NRI: Norepinephrine reuptake inhibitors.

Citation: Telles-Correia D, Barbosa A, Cortez-Pinto H, Campos C, Rocha NBF, Machado S. Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity. World J Gastrointest Pharmacol Ther 2017; 8(1): 26-38
URL: https://www.wjgnet.com/2150-5349/full/v8/i1/26.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v8.i1.26