Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 370-386
Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.370

Table 3 Mechanisms of pain in chronic pancreatitis

Increased intraductal pressure

Ductal obstruction from strictures/stones

Increased intrapancreatic pressure (compartment-like syndrome)

Fibrosis causing lack of distensibility

Neuropathic

Entrapment of nerves

Damage of nerves by enzymes

Increased nerve tissue

Pancreatic ischemia

Worsened during increased enzyme secretion

Citation: Hobbs PM, Johnson WG, Graham DY. Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes. World J Gastrointest Pharmacol Ther 2016; 7(3): 370-386
URL: https://www.wjgnet.com/2150-5349/full/v7/i3/370.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v7.i3.370

Hobbs PM, Johnson WG, Graham DY. Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes. World J Gastrointest Pharmacol Ther 2016; 7(3): 370-386 [PMID: 27602238 DOI: 10.4292/wjgpt.v7.i3.370]

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