Clinical utility of quantitative multi-antibody Polycheck immunoassays in the diagnosis of coeliac disease

Table 3 Antibody profile in celiac disease patients and non-celiac disease controls

Anti-tTG-IgA	Anti-tTG-IgG	Anti-DGP-IgA	Anti-DGP-IgG	CD patientsn = 50	Non-CD controlsn = 50	Totaln = 100	Classification in combination (anti-tTG-IgA/IgG + anti-DGP-IgG/IgA)
+	+	+	+	7 (14%)	0	7	49 positives
+	+	-	+	11 (22%)	0	11
+	-	+	+	8 (16%)	0	8
+	-	-	+	17 (34%)	0	17
-	+	-	+	61 (12%)	0	6
-	-	-	+	1 (2%)	2 (4%)	3	5 not classified
-	-	+	-	0	1 (2%)	1
-	+	-	-	0	1 (2%)	1
-	-	-	-	0	46 (92%)	46	46 negatives

¹Patients with confirmed selective IgA deficiency. +: Antibody present; -: Antibody absent; Using the combination of four antibodies (anti-tTG-IgA/IgG + anti-DGP-IgG/IgA) classified 49 children as CD positive, 46 as CD negative, and 5 were neither classified as CD positive nor negative with further verification needed. CD: Celiac disease; DGP: Deamidated gliadin peptides; tTG: Tissue transglutaminase.