Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis

doi:10.4292/wjgpt.v6.i4.213

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Nov 6, 2015; 6(4): 213-222
Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.213

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Figure 2 Plecanatide and dolcanatide mediated stimulation of cyclic guanosine monophosphate production in T84 cells. The potency of plecanatide and dolcanatide to stimulate cGMP production was evaluated using the T84 cell bioassay (see Materials and Methods). The data presented are an average of three determinations and are expressed as pmoles cGMP/mg protein ± SD. cGMP: Cyclic guanosine monophosphate.

Citation: Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther 2015; 6(4): 213-222
URL: https://www.wjgnet.com/2150-5349/full/v6/i4/213.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v6.i4.213

Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther 2015; 6(4): 213-222 [PMID: 26558155 DOI: 10.4292/wjgpt.v6.i4.213]

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