Age-related differences in celiac disease: Specific characteristics of adult presentation

Table 2 Diagnostic criteria for celiac disease proposed by Catassi and Fasano[22]

The presence of signs and symptoms compatible with celiac disease

Positivity of serum celiac disease IgA class autoantibodies at high titer

Presence of the predisposing genes HLA-DQ2 and/or -DQ8

Celiac enteropathy at the small intestinal biopsy1

Resolution of the symptoms and normalization of serology test following the implementation of a gluten-free diet2

¹Including Marsh-Oberhuber 3 lesions, Marsh-Oberhuber 1-2 lesions associated with positive celiac antibodies positive at low/high titer, or Marsh-Oberhuber 1-3 lesion associated with IgA subepithelial deposits;

²Histological normalization in patients with sero-negative celiac disease or associated IgA deficiency. At least 4 of 5 (or 3 of 4 if the HLA genotype is not performed). HLA: Human leukocyte antigen.