Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice

Table 1 Effects of insulin and prokinetic drugs alone and in combination on small intestinal transit and gastric emptying in diabetic mice

Treatments	SIT (%)	GE (%)
Normal control (citrate buffer)	56.61 ± 2.58	72.50 ± 1.68
Diabetic control (streptozotocin 100 mg/kg)	76.90 ± 6.12a	55.23 ± 9.30a
Insulin (2 IU/kg s.c.)	61.05 ± 3.85c	95.87 ± 2.41ac
Metoclopramide (20 mg/kg p.o.)	50.04 ± 2.42ce	76.38 ± 7.67ce
Insulin (2 IU/kg s.c.) +Metoclopramide (20 mg/kg p.o.)	54.30 ± 3.46c	94.91 ± 1.01ac
Domperidone (20 mg/kg p.o.)	48.70 ± 4.53ce	90.92 ± 4.92ac
Insulin (2 IU/kg s.c.) +Domperidone (20 mg/kg p.o.)	62.60 ± 3.07c	92.87 ± 1.14ac
Erythromycin (6 mg/kg p.o.)	43.05 ± 3.50ce	84.77 ± 2.11c
Insulin (2 IU/kg s.c.) +	49.14 ± 4.57ce	90.86 ± 3.20ac
Erythromycin (6 mg/kg p.o.)

Values represent the mean ± SE of eight mice per group. Significantly different from the normal control value at

^aP < 0.05; Significantly different from the diabetic control value at

^cP < 0.05; Significantly different from insulin value at

^eP < 0.05. SIT: Small intestinal transit; GE: Gastric emptying.