Fructose malabsorption associated with functional abdominal bloating: Case-control study

doi:10.4292/wjgpt.v17.i2.121264

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 121264
Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.121264

Table 3 Univariate analysis of conditions and symptoms associated with the detection of fructose malabsorption by a fructose breath test, n (%)/median (range)

Characteristics	FHBT positive (n = 20)	FHBT negative (n = 50)	P value
Age (years)	26.5 (19-74)	36 (18-65)	0.01
Gender	Females: 15 (75)	Females: 19 (38)	0.01
Duration of symptoms (years)	2 (1-15)	2 (1-10)	0.69
BMI (kg/m²)	21.3 (12.5-26.6)	22.4 (15.6-31.2)	0.25
Dietary pattern	Mixed: 13 (65)	Mixed: 39 (78)	0.26
Bristol score (> 4)	5 (25)	3 (6)	0.26
Severity of bloating (severe)	9 (45)	12 (24)	0.20
PPI usage	16 (80)	47 (94)	0.07
Prokinetics	8 (40)	13 (26)	0.24
Abdominal distension	19 (95)	49 (98)	1.0
Belching	1 (5)	5 (10)	0.50
Flatulence	1 (5)	1 (2)	0.49
Nausea	3 (15)	3 (6)	0.22
Abdominal pain	2 (10)	5 (10)	1.0
Epigastric discomfort	9 (45)	8 (16)	0.01
Mucus in stools	5 (25)	4 (8)	< 0.05
Constipation	6 (30)	15 (30)	1.00
Loose stools	1 (5)	3 (6)	0.86

FHBT: Fructose hydrogen breath test; BMI: Body mass index; PPI: Proton pump inhibitor.

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Citation: Kulandaivelu A, Vaithiyam V, Mehta K, Reddy RT, Ahuja A, Sirohi N, Sonika U, Dalal A, Kumar A, Puri AS, Sachdeva S. Fructose malabsorption associated with functional abdominal bloating: Case-control study. World J Gastrointest Pharmacol Ther 2026; 17(2): 121264
URL: https://www.wjgnet.com/2150-5349/full/v17/i2/121264.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v17.i2.121264

Kulandaivelu A, Vaithiyam V, Mehta K, Reddy RT, Ahuja A, Sirohi N, Sonika U, Dalal A, Kumar A, Puri AS, Sachdeva S. Fructose malabsorption associated with functional abdominal bloating: Case-control study. World J Gastrointest Pharmacol Ther 2026; 17(2): 121264 [PMID: 42273237 DOI: 10.4292/wjgpt.v17.i2.121264]

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