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Copyright: ©Author(s) 2026.
World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 118778
Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.118778
Table 8 Risk factors for postoperative recurrence in Crohn’s disease
Risk factor
Effect on recurrence
Active cigarette smokingStrongest modifiable predictor; higher endoscopic and surgical recurrence
Penetrating phenotype, perianal CDIncreased early endoscopic and clinical recurrence
Prior intestinal resectionHigher risk of further surgery and earlier recurrence
Extensive small-bowel resectionIncreased recurrence and nutritional complications
Absence or delay of biologic prophylaxisHigher endoscopic recurrence vs early anti-TNF therapy


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