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Systematic Reviews
Copyright: ©Author(s) 2026.
World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 118778
Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.118778
Table 7 Early surgery vs prolonged medical therapy in localized ileocaecal Crohn’s disease
Aspect
Early ileocolic resection
Prolonged/optimized medical therapy (e.g., anti-TNF)
Primary aimRapid symptom control and removal of diseased segment Long-term inflammation control and bowel preservation
Short-term outcomesFaster symptom relief; fewer steroids; good QoLAvoids surgical risk initially; some avoid surgery long-term
Long-term surgery needMany will need further surgery over time Substantial proportion ultimately require surgery
Strategy implicationsFavored for stricturing/penetrating localized disease in fit patientsFavored when extensive small bowel involvement or high surgical risk


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