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Systematic Reviews
Copyright: ©Author(s) 2026.
World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 118778
Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.118778
Table 3 Ileal pouch-anal anastomosis vs permanent end ileostomy in ulcerative colitis
Domain
IPAA (ileal pouch-anal anastomosis)
Permanent end ileostomy
Disease controlRemoves colon/rectum; pouchitis common long-term Removes colon/rectum; no pouchitis risk
Bowel function5-8 BMs/day, some urgency/soilage; improves over time 4-6 stoma emptyings/day; predictable but appliance-dependent
Major complicationsPouchitis, pelvic sepsis, strictures, pouch failure Parastomal hernia, skin problems, retraction/prolapse
Quality of life (global)Generally “better or much better” than pre-op in > 80% of patients Often improved vs pre-op; many report good HRQOL but with body-image issues
Sexual functionSmall but real risk of pelvic nerve injury; most maintain function Less pelvic dissection if rectum spared; function often preserved
Decisional aspectsMore complex risk–benefit discussion; strong preference to avoid stomaSome patients prefer predictable stoma to fear of pouch failure


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