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Systematic Reviews
Copyright: ©Author(s) 2026.
World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 118778
Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.118778
Table 2 Key surgical options in ulcerative colitis
Procedure
Main indication
Advantages
Limitations/risks
Subtotal colectomy with end ileostomyEmergency toxic megacolon, perforation, severe colitis Rapid source control; avoids pelvic dissectionPermanent stoma if no later reconstruction; rectal stump issues
Total proctocolectomy + IPAA (J-pouch)Medically refractory UC; dysplasia/cancerNo colon/rectum; continence preserved; no permanent stomaPouchitis, pelvic sepsis, sexual/urinary dysfunction, pouch failure
Total colectomy + ileorectal anastomosisMild rectal disease; fertility concerns; high-risk for IPAAEasier operation, better pelvic nerve preservation Ongoing rectal disease; cancer surveillance required
Permanent end ileostomyUnfit for restorative surgery; failed pouch; patient choiceTechnically straightforward; reliable symptom controlBody image concerns; stoma complications; appliance dependence


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