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Copyright: ©Author(s) 2026.
World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 118778
Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.118778
Table 1 Indications for surgery in ulcerative colitis and Crohn’s disease
Feature
Ulcerative colitis
Crohn’s disease
Main elective indicationMedically refractory pancolitis/proctitis despite optimized biologicsFibro-stenotic obstruction, penetrating complications, failure of medical therapy
Cancer/dysplasia indicationVisible or high-grade dysplasia, multifocal or nonresectable lesions Colitis-associated dysplasia in colonic CD; often managed similarly to UC
Emergency indicationsToxic megacolon, perforation, massive hemorrhage, fulminant colitisPerforation, uncontrolled hemorrhage, fulminant colitis, sepsis from penetrating disease
Typical index operationSubtotal colectomy with end ileostomy or proctocolectomy with IPAAIleocolic resection, segmental resection, or stricturo-plasty


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