Evolving prokinetic therapy: New targets and therapeutic opportunities in gastrointestinal motility disorders

doi:10.4292/wjgpt.v17.i2.118616

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 118616
Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.118616

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Figure 3 Safety profiles of prokinetic agents. Overview of major prokinetic drug classes and their characteristic adverse effects, highlighting differences between older agents with significant systemic risks and newer therapies with generally milder or localized safety concerns. CB1: Cannabinoid receptor type 1; CB2: Cannabinoid receptor type 2; CNS: Central nervous system; D2: Dopamine type 2 receptor; GES: Gastric electrical stimulation; GI: Gastrointestinal; NHE3: Sodium-hydrogen exchanger 3; 5-HT4: 5-Hydroxytryptamine type 4 receptor.

Citation: Goyal O, Chowdhary R, Sehgal T, Joshi T, Bhambri A, Rampurawala IM, Sohi GS, Das A, Arora K, Vuthaluru AR, Goyal MK. Evolving prokinetic therapy: New targets and therapeutic opportunities in gastrointestinal motility disorders. World J Gastrointest Pharmacol Ther 2026; 17(2): 118616
URL: https://www.wjgnet.com/2150-5349/full/v17/i2/118616.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v17.i2.118616

Goyal O, Chowdhary R, Sehgal T, Joshi T, Bhambri A, Rampurawala IM, Sohi GS, Das A, Arora K, Vuthaluru AR, Goyal MK. Evolving prokinetic therapy: New targets and therapeutic opportunities in gastrointestinal motility disorders. World J Gastrointest Pharmacol Ther 2026; 17(2): 118616 [PMID: 42273241 DOI: 10.4292/wjgpt.v17.i2.118616]

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