Mechanism of Xiaozhiling injection in the treatment of internal hemorrhoids based on changes in perianal blood flow and rectal submucosal fibers

doi:10.4292/wjgpt.v17.i1.113444

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 113444
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.113444

Table 2 Rectal submucosal thickness (μm) at different periods after Xiaozhilin injection in rats with internal haemorrhoids

Group	A (1)	B (2)	C (3)	D (4)	E (5)	F (6)	G (7)
Submucosal thickness	132.02 ± 3.221¹	378.111 ± 39.967²	401.056 ± 40.011³	440.631 ± 47.414³	352.146 ± 39.987³	219.707 ± 32.48⁴	194.825 ± 37.013⁴
F	62.381
P value	0.001
LSD	(1) < (2), (1) < (3), (1) < (4), (1) < (5), (1) < (6), (1) < (7), (2) < (4), (2) > (6), (2) > (7), (3) > (5), (3) > (6), (3) > (7), (4) > (5), (4) > (6), (4) > (7), (5) > (6), (5) > (7)

¹Group A shows significant differences from the other groups.

²Group B showed no significant differences from group C and group E, respectively.

³There was no significant difference between Group C and Group D.

⁴There was no significant difference between groups F and G.

A: Model; B: 8 hours after drug injection; C: 3 days after drug injection; D: 1 week after drug injection; E: 2 weeks after drug injection; F: 1 month after drug injection; G: 4 months after drug injection; LSD: Least significant difference.

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Citation: Huang SY, Lin WG, Lan H, Xu ZG, Zheng XX, Liu XB, Cheng YM, Li ZF, Ke MH. Mechanism of Xiaozhiling injection in the treatment of internal hemorrhoids based on changes in perianal blood flow and rectal submucosal fibers. World J Gastrointest Pharmacol Ther 2026; 17(1): 113444
URL: https://www.wjgnet.com/2150-5349/full/v17/i1/113444.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v17.i1.113444

Huang SY, Lin WG, Lan H, Xu ZG, Zheng XX, Liu XB, Cheng YM, Li ZF, Ke MH. Mechanism of Xiaozhiling injection in the treatment of internal hemorrhoids based on changes in perianal blood flow and rectal submucosal fibers. World J Gastrointest Pharmacol Ther 2026; 17(1): 113444 [PMID: 41809221 DOI: 10.4292/wjgpt.v17.i1.113444]

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