Acid peptic disorder compass: An Indian expert consensus on comprehensive management

Table 3 Use of acid suppressants in special populations

Treatment	Indication	Dose/frequency	Risk/conditions
Renal impairment
Ranitidine[19]	GERD	150 mg OD	Risk of toxic reactions: In elderly patients with reduced renal function, in patients with hepatic dysfunction
Famotidine[21]	Erosive esophagitis	20 mg OD or 40 mg every other day	Risk of CNS adverse reactions and QT prolongation in moderate and severe renal impairment
	GU/DU
Vonoprazan[63]	Erosive esophagitis	10/20 mg OD	Not recommended: In severe renal impairment (eGFR < 30 mL/minute), for maintenance of healed erosive esophagitis
	H. pylori eradication	20 mg BD
Hepatic impairment
Vonoprazan[63]	Erosive esophagitis	10/20 mg OD	Not recommended for H. pylori eradication in moderate to severe hepatic impairment
	H. pylori eradication	20 mg BD

BD: Twice-daily; CNS: Central nervous system; DU: Duodenal ulcer; eGFR: Estimated glomerular filtration rate; GERD: Gastroesophageal reflux disease; GU: Gastric ulcer; OD: Once-daily; H. pylori: Helicobacter pylori.