Acid peptic disorder compass: An Indian expert consensus on comprehensive management

doi:10.4292/wjgpt.v17.i1.112615

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Expert Consensus

World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 112615
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.112615

Table 2 Pharmacokinetics of proton pump inhibitors

Agents	Bioavailability (%)	T_max (hour)	C_max (mg/mL)	Protein binding (%)	T_1/2 (hour)	pKa	AUC 0-24 (mg/hour/L)	V (L/kg)	CL (mL/minute)
Esomeprazole	64-90	1.5	1.5	97	1-1.5	4.0	2.0	160-330	1.3-1.6
Dexlansoprazole	-	4-5	-	96	1-2	4.0	-	-	-
Pantoprazole	77	2-3	2.5	98	1-1.9	3.9	5.0	90-225	0.8-2.0
Rabeprazole	52	2-5	0.4	96.3	1-2	5.0	0.8	-	0.6-1.4
Omeprazole	30-40	0.5-3.5	0.7	95	0.5-1	4.0	2.0	400-620	0.5-1.2
Lansoprazole	80-85	1.7	0.5-1.0	97	1.6	4.0	2.5	400-650	0.9-2.1

AUC: Area under the curve; CL: Clearance; T_max: Time to peak plasma level; C_max: Maximum plasma concentration; T_1/2: Half-life; V: Apparent volume of distribution.

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Citation: Sinha SK, Kochhar R, Rao KS, Yadav D, Ray S, Singh AP, Sethy PK, Mahajan R, Reddy DV, Sharma VM, Kumar A, Mishra A, Jain S, Swami OC, Patil D. Acid peptic disorder compass: An Indian expert consensus on comprehensive management. World J Gastrointest Pharmacol Ther 2026; 17(1): 112615
URL: https://www.wjgnet.com/2150-5349/full/v17/i1/112615.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v17.i1.112615

Sinha SK, Kochhar R, Rao KS, Yadav D, Ray S, Singh AP, Sethy PK, Mahajan R, Reddy DV, Sharma VM, Kumar A, Mishra A, Jain S, Swami OC, Patil D. Acid peptic disorder compass: An Indian expert consensus on comprehensive management. World J Gastrointest Pharmacol Ther 2026; 17(1): 112615 [PMID: 41809210 DOI: 10.4292/wjgpt.v17.i1.112615]

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