Acid peptic disorder compass: An Indian expert consensus on comprehensive management

Table 1 Acid suppression therapy for acid peptic disorders

Ref.	GERD	Reflux/erosive esophagitis	NERD	PUD/H. pylori eradication
Bhatia et al[16], 2020; Yadlapati et al[17], 2022; Iwakiri et al[18], 2022; ZANTAC® SmPC[19]	Rabeprazole 20 mg OD	Vonoprazan 20 mg OD for 4 weeks (in mild condition)	Ranitidine 150 mg TID	Vonoprazan 20 mg BD (dual/triple therapy)
Iwakiri et al[18], 2022; NEXIUM SmPC[20]; PEPCID® SmPC[21]	Esomeprazole 20/40 mg OD	Vonoprazan 20 mg + prokinetics (in severe condition) for 8 weeks	Famotidine 20 mg BD	Esomeprazole 40 mg OD
Bhatia et al[16], 2020; Yadlapati et al[17], 2022; Farrell et al[22], 2017	Dexlansoprazole 30 mg OD	Esomeprazole 40 mg OD	Esomeprazole 20 mg OD	Rabeprazole 20 mg OD (post-breakfast) for up to 4 weeks
PROTONIX SmPC[23]; DEXILANT SmPC[24]; Central Drugs Standard Control Organization Government of India[25]	Pantoprazole 40 mg OD	Dexlansoprazole 30/60 mg OD	Dexlansoprazole 30 mg OD	Ilaprazole 5-10 mg OD
ZANTAC® SmPC[19]; PEPCID® SmPC[21]; ACIPHEX® SmPC[26]; PRILOSEC SmPC[27]	Famotidine 40 mg OD	Ranitidine 150 mg QID	Rabeprazole 20 mg OD	Omeprazole 20 mg BD or 40 mg OD
ZANTAC® SmPC[19]; PEPCID® SmPC[21]; Central Drugs Standard Control Organization Government of India[28]	Ranitidine 150 mg BD	Famotidine 20/40 mg TID		Lafutidine 5-10 mg

BD: Twice-daily; GERD: Gastroesophageal reflux disease; GU: Gastric ulcer; NERD: Non-erosive reflux disease; OD: Once-daily; PUD: Peptic ulcer disease; QID: Four times a day; TID: Three times a day; H. pylori: Helicobacter pylori.