L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin

doi:10.4292/wjgpt.v16.i4.111977

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Dec 5, 2025; 16(4): 111977
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.111977

Table 2 Scoring for histopathological changes

Histopathological changes	Scoring
Histopathological changes	NC	MC	Pir	Sim	Pir + sim
Inflammatory cell infiltration	0	3	1	1	1
Congestion	0	3	1	2	1
Fatty replacement of exocrine pancreas	0	3	1	1	1
Areas of abnormal pancreatic tissue architecture from the total parenchyma¹	0¹	3¹	2¹	1¹	1¹
Glandular atrophy	0	3	1	0	0
Fibrosis/collagen deposition in exocrine pancreas (Masson’s trichome stain)	0	3	1	1	0
Distortion/degeneration of exocrine pancreas	0	3	2	1	1

¹The following grading was applied: 0 (absent); 1 (minimal); 2 (moderate); 3 (severe); 0¹ (absent); 1¹ (rare); 2¹ (minimal < 10% area); 3¹ (moderate < 50% area); and 4¹ (major > 50% area).

NC: Normal control; MC: Model control: Pir: Pirfenidone; Sim: Simvastatin.

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Citation: Mehta R, Patel A, Vyas B, Desai B, Adhvaryu D, Sojitra P, Bhuptani S. L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin. World J Gastrointest Pharmacol Ther 2025; 16(4): 111977
URL: https://www.wjgnet.com/2150-5349/full/v16/i4/111977.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v16.i4.111977

Mehta R, Patel A, Vyas B, Desai B, Adhvaryu D, Sojitra P, Bhuptani S. L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin. World J Gastrointest Pharmacol Ther 2025; 16(4): 111977 [PMID: 41383569 DOI: 10.4292/wjgpt.v16.i4.111977]

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