Intestinal-related substances in obesity regulation: A comprehensive review

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Dec 5, 2025; 16(4): 111082
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.111082

Table 2 The role of short-chain fatty acid in the gut

Affiliation	Method	Result	Conclusion	Ref.
Institute of Microecology, Germany	Controlled human study comparing SCFA levels across BMI groups	SCFA levels were significantly higher in obese and overweight groups vs healthy individuals	The acetate/propionate/butyrate ratio modulates obesity development	[24]
Imperial College London, United Kingdom	Nanoparticle-based acetate intervention in HFD-induced obese mice	Acetate improved liver mitochondrial function and reduced lipid accumulation	Anti-obesity effects of acetate: (1) Reduces hepatic lipid accumulation; and (2) Enhances systemic thermogenesis	[17]

SCFA: Short-chain fatty acid; BMI: Body mass index; HFD: High-fat diet.

Citation: Wang SY, Zhang MZ, Chen ZM, Li ZM, Xie CY, Yang GH, Xu B, Xu TC. Intestinal-related substances in obesity regulation: A comprehensive review. World J Gastrointest Pharmacol Ther 2025; 16(4): 111082
URL: https://www.wjgnet.com/2150-5349/full/v16/i4/111082.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v16.i4.111082

Wang SY, Zhang MZ, Chen ZM, Li ZM, Xie CY, Yang GH, Xu B, Xu TC. Intestinal-related substances in obesity regulation: A comprehensive review. World J Gastrointest Pharmacol Ther 2025; 16(4): 111082 [PMID: 41378072 DOI: 10.4292/wjgpt.v16.i4.111082]

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