Enteric nervous system as a therapeutic target in gastrointestinal disorders

Table 3 Studies showing therapeutic role of enteric nervous system on gastrointestinal motility disorders

No.	Ref.	Study characteristics	Key role of ENS
1	Bessard et al[112]	Investigates alterations in prostanoid expression and intestinal epithelial barrier functions that contribute to ileus	Highlights how disruptions in ENS signaling and epithelial function lead to impaired motility and ileus development
2	Bonaz[113]	Discusses the role of enteric neuropathy and the vagus nerve in gastrointestinal disorders, with therapeutic implications	Explores how enteric neuropathy and vagal signaling impact gut function, offering insights into treatment strategies
3	Brun et al[114]	Studies how Toll-like receptor-2 regulates glial-derived neurotrophic factor production in intestinal smooth muscle cells	Focuses on how glial cells in the ENS influence smooth muscle function and gut motility via neurotrophic factor production
4	Ferreira-Duarte et al[115]	Explores the interaction between the renin-angiotensin system and enteric neurotransmission in colonic dysmotility in TNBS-induced colitis	Highlights the interplay between systemic signaling and the ENS, leading to dysmotility in inflammatory conditions like colitis
5	Filpa et al[116]	Investigates the role of glutamatergic neurotransmission in the ENS and its role in the brain-gut axis in health and disease	Explores how glutamate signaling in the ENS influences gut-brain communication and impacts gastrointestinal disorders
6	Floettmann et al[117]	Provides the pharmacological profile of Naloxegol, a peripherally acting μ-opioid receptor antagonist for opioid-induced constipation	Focuses on the interaction between opioid receptors in the ENS and peripheral opioid antagonism to treat constipation
7	Gao et al[118]	Investigates μ-opioid receptor-mediated enteric glial activation in morphine-induced constipation	Highlights the activation of enteric glia through opioid receptors, contributing to constipation in opioid use
8	Sanger et al[119]	Discusses the role of ghrelin and motilin control systems in gastrointestinal physiology and therapeutics	Explores the control of gastrointestinal motility via ghrelin and motilin systems, which interact with the ENS for motility regulation
9	Stakenborg et al[120]	Reviews pathophysiology and current therapeutic approaches to postoperative ileus	Discusses how the ENS is involved in the pathophysiology of ileus and how therapies targeting ENS dysfunction can improve recovery

ENS: Enteric nervous system; TNBS: Trinitrobenzenesulfonic acid.