Enteric nervous system as a therapeutic target in gastrointestinal disorders

Table 2 Studies showing therapeutic role of enteric nervous system on inflammatory bowel disease

No.	Ref.	Study characteristics	Key role of ENS
1	Belarif et al[91]	Investigates the influence of the IL-7 receptor on anti-TNF responsiveness and T-cell gut homing in IBD	Focuses on how the IL-7 receptor affects the ENS by influencing T-cell migration and responsiveness to anti-TNF therapy
2	Boldyreva et al[92]	Highlights the gut-brain axis and non-obvious factors involved in IBD	Explores the communication between the ENS and brain, and how it impacts the development and progression of IBD
3	Bosáková et al[93]	Studies the role of serotonin in attenuating TNF-induced intestinal inflammation through interaction with human mucosal tissue	Investigates serotonin's effects on the ENS and its potential to modulate inflammation in the gut via interaction with mucosal tissue
4	Hawker et al[94]	Explores the role of Mas-related G protein-coupled receptors in gastrointestinal dysfunction and IBD	Examines the involvement of Mas-related receptors in ENS-mediated gastrointestinal functions, particularly in IBD
5	Lê et al[95]	Reviews therapeutic strategies for IBD involving modulation of the microbiota and the introduction of pre-, pro-, syn-, or postbiotics	Focuses on how microbiota manipulation impacts ENS function, providing new therapeutic strategies for IBD management
6	Ochoa-Cortes et al[96]	Discusses enteric glial cells as a new frontier in neurogastroenterology and a potential clinical target for IBD	Highlights the growing importance of enteric glial cells in IBD, providing potential new targets for clinical treatment
7	Robinson et al[97]	Investigates the neuroprotective effects of bone marrow mesenchymal stem cells in TNBS-induced colitis	Demonstrates how stem cells interact with the ENS to protect against damage and restore function in gastrointestinal disorders
8	Sahakian et al[98]	Identifies molecular targets to alleviate enteric neuropathy and gastrointestinal dysfunction	Focuses on targeting specific molecules in the ENS to relieve neuropathy and restore normal gastrointestinal function
9	Stavely et al[99]	Explores strategies for targeting enteric neurons and plexitis as a way to manage IBD	Emphasizes the role of enteric neurons and the plexuses in managing inflammation and dysfunction in IBD

ENS: Enteric nervous system; IBD: Inflamatory bowel disease; TNF: Tumor necrosis factor; TNBS: Trinitrobenzenesulfonic acid.