Electroacupuncture alleviates symptoms and identifies a potential microbial biomarker in patients with constipation-predominant irritable bowel syndrome

Figure 4 Gut composition in irritable bowel syndrome with predominant constipation responders to electroacupuncture and irritable bowel syndrome with predominant constipation non-responders to electroacupuncture. A: Differential abundance calculated by Analysis of the Composition of Microbiomes with Bias Correction are presented as bar plots of beta coefficients and standard error of beta. Orange and blue colors represent positive and negative associations respectively, with the corresponding columns; B: Shared differentially abundant genera across responders and non-responder to electroacupuncture in patients with irritable bowel syndrome with predominant constipation by Venn diagram; C: Correlation between electroacupuncture-responsive bacterial and change in clinical scores. Only taxa with significant associations after being adjusted with the Bonferroni correction are presented. ^aP < 0.01. ACP: Irritable bowel syndrome patients after electroacupuncture; HAD: Hospital Anxiety and Depression Scale in the part of anxiety; IBS: Irritable bowel syndrome patients; IBSS: Irritable bowel syndrome symptom severity scale scores; IBSQ: Irritable bowel syndrome quality of life; MDA: Malondialdehyde.