Overview of drug induced liver injury in Brazil: What is the role of public health policy on the evidence?

Table 3 Main outcomes related to drug-induced liver injury in Brazilian studies

Ref.	DILI outcomes	Medications
Santos et al[23], 2019	6 Cases were resolved after the suspension of medications	Tuberculostatic
Magalhães[26], 2015	21 Cases were resolved after the suspension of the substance, but without the use of medications; 9 cases were resolved with the suspension of the substance associated with medications; 1 case with acute hepatic failure, requiring liver transplantation	Isoniazid, valproic acid, amitriptyline, cyclosporine, clozapine, dasatinib, imatinib, ACO, simvastatin, melphalan, and others
Antonello et al[55], 2014	There was no need to suspend or change the treatment	ARV
Kondo et al[49], 2008	7/157 Patients (4.4%) were hospitalized and, after discontinuation of Nevirapine, all presented clinical and laboratory improvement	Nevirapine
Brito et al[64], 2014	Changed therapeutic regimen in all who developed DILI 15/245 (6.1%)	RHZ
Lima Mde et al[65], 2012	Drug maintenance 26/156 (16.6%), temporary interruption 12/156 (7.7%), treatment change 11/156 (7%), suspension of medications TB 7/156 (4.5%)	RHZ, RHZE
Coca et al[73], 2010	Medication suspended in 7/30 (23.3%) HIV and 15/132 (11.4%) non-HIV	RHZ
Vieira et al[79], 2008	There was a need to modify the treatment regimen in 11/24 (45%) of the patients	RHZ
Picon et al[66], 2002	RHZ: 45 cases changed treatment; SHM: 1 case changed treatment	RHZ, SHM
Gusmão Filho et al[43], 2001	3/52 (5.76%) Required replacement of the medication. In 16/52 (30.7%) there was no need for intervention and in other 13/52 (25%) only the doses of Isoniazid and Rifampicin were changed	RHZ, RHE
de-Medeiros et al[75], 1998	Medication was suspended and 1/37 (2%) patient was excluded from the RCT	Tretinoin
Alves et al[59], 2011	Medication doses were temporarily reduced	MTX
Prado et al[27], 2019	The culprit drug was discontinued, and drug therapy was not necessary to resolve the problem in 3 patients	Nimesulide, budesonide, valacyclovir
Werner et al[61], 1989	There was clinical and laboratory Improvement with the suspension of the medication in 4/389 (1%) and 1/389 (0.25%) evolved to chronic hepatitis	Methimazole, Propylthiouracil

DILI: Drug-induced liver injury; R: Rifampicin H: Isoniazid; Z: Pyrazinamide; S: Streptomycin; and E: Ethambutol; RCT: Randomized clinical trial; MTX: Methotrexate; ARV: Antiretroviral; ACO: Oral contraceptives.