Oral encapsulated transforming growth factor β1 reduces endogenous levels: Effect on inflammatory bowel disease

Figure 1 Release profiles of transforming growth factor -loaded poly-lactic acid microspheres and all trans retinoic acid-loaded poly-lactic-co-glycolic acid microspheres. Transforming growth factor (TGF) was encapsulated in poly-lactic acid (PLA) microspheres (285 μg of TGF per gram of particles) using Phase Inversion Nano-encapsulation (PIN). All trans retinoic acid (ATRA) was encapsulated into poly-lactic-co-glycolic acid (PLGA) microspheres (1 mg of ATRA per gram of particles) using a modification of the solvent evaporation technique (see methods section). A: TGF-loaded microspheres were release-tested using the in vitro release assay as described in the methods section; B: ATRA-loaded microspheres were release-tested using an in vitro extraction assay as described in the methods section. Data are expressed as pg/mL or as μg/mL ± SE. TGFβ: Transforming growth factor ; ATRA: All trans retinoic acid.