Gastrointestinal symptoms in acromegaly: A case control study

Table 3 Gastrointestinal symptoms in acromegaly patients compared with controls

		Controls, n = 200 (%)	Acromegaly patients, n = 50 (%)	P value (Fisher’s exact test)
Oesophageal disorders
	Functional chest pain	2 (1%)	3 (6%)	0.0561
	Functional heartburn	22 (11%)	15 (30%)	0.0016b
	Globus	2 (1%)	2 (4%)	0.1796
	Functional dysphagia	4 (2%)	6 (12%)	0.0053b
Gastroduodenal disorders
	Functional dyspepsia	14 (7%)	12 (24%)	0.0013b
	Belching disorders	8 (4%)	5 (10%)	0.1441
	Nausea and vomiting disorders	2 (1%)	2 (4%)	0.1796
	Rumination syndrome	2 (1%)	1 (2%)	0.4895
Bowel disorders
	Irritable bowel syndrome	12 (6%)	10 (20%)	0.0041b
	Functional constipation	22 (11%)	34 (68%)	0.0006b
	Functional diarrhoea	10 (5%)	9 (18%)	0.0048b
	Functional abdominal bloating/distension	12 (6%)	11 (22%)	0.0015b
	Unspecified functional bowel disorder	44 (22%)	25 (50%)	0.0002b
Centrally mediated Abdominal pain syndrome		6 (3%)	4 (8%)	0.1165
Functional Biliary pain		1 (0.5%)	3 (6%)	0.0261a
Anorectal disorders
	Faecal incontinence	1 (0.5%)	2 (4%)	0.1028
	Functional anorectal pain	2 (1%)	4 (8%)	0.0157a

^aP < 0.05,

^bP < 0.01, statistically significant.