Hepatic encephalopathy therapy: An overview

Table 2 RCTs on the treatment of MHE

Ref.	Type of study	Type of HE/patients (n)	Tested treatment	Control treatment	Results
Prasad et al[46] 2007	RCT	MHE (61)	Lactulose (30-60 mL of lactulose in 2 or 3 divided doses)	No treatment	Lactulose improved the quality of life
Bajaj et al[41] 2008	Prospective randomized trial	MHE (25)	Probiotic yoghurt	No treatment	Probiotic improved the psychometric performance
Liu et al[73] 2004	Double blind, randomized study	MHE (55)	Bioactive, fermentable fibers and lactic acid bacteria Bioactive, fermentable fibers	Placebo	Synbiotic treatment improved the psychometric performance and the Child-Turcotte-Pugh class
Malaguarnera et al[74] 2009	Randomized study	MHE (125)	Bifidobacterium + fructo-oligosaccharides	Lactulose	Both treatments improve blood ammonia and psychometric performance

MHE: Minimal hepatic encephalopathy.