Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice

Figure 1 Epididymal fat pad weights and serum transaminase concentrations are decreased by curcumin and vitamin E combination therapy. Hfe^-/- mice were fed HCD for 10 wk then HCD + Cu, HCD + VE or HCD + Cu + VE for a further 10 wk (n = 7-9). A: Body, liver and epididymal fat pad weights were determined. B: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations were determined on final cardiac bleeds. Following sacrifice, a dried liver segment was digested to determine hepatic iron concentration (HIC). Data are depicted using box and whisker plots showing median, minimum and maximum values. Statistical significance was tested using Kruskal-Wallis test with Dunn’s correction for multiple comparisons, ^aP ≤ 0.05. HCD: High calorie diet; Cu: Curcumin; VE: Vitamin E.