Hypoallergenic formula with Lactobacillus rhamnosus GG for babies with colic: A pilot study of recruitment, retention, and fecal biomarkers

Table 2 Longitudinal analysis of clinical variables by study group (LGG+ vs LGG-) at baseline and follow up visits

	Adjusted means (95%CI)			P value
	LGG+ group	LGG- group	Mean differences(95%CI)
Crying + fussing time (min)
Visit 1 (Baseline)	296 (210, 381)	337 (251, 422)	41 (-80, 161)	0.51
Visit 2	197 (117, 278)	289 (142, 436)	91 (-76, 259)	0.29
Visit 3	144 (54, 234)	199 (69, 328)	55 (-104, 213)	0.50
Visit 4	111 (65, 157)	133 (60, 205)	22 (-64, 107)	0.62
Fecal calprotectin (μg/g)
Visit 1 (Baseline)	285 (199, 371)	294 (184, 404)	9 (-131, 149)	0.90
Visit 2	226 (182, 270)	305 (186, 423)	79 (-48, 205)	0.22
Visit 3	229 (113, 345)	250 (154, 347)	21 (-130, 172)	0.78
Visit 4	211 (80, 342)	332 (225, 440)	121 (-48, 291)	0.16

Longitudinal model: Barr Diary data = β₀ + β₁× visit2 + β₂× visit3 + β₃× visit4 + β₄ group + β₅× visit2 group + β₆× visit3 group + β₇× visit4 group. Here, visit2, visit3, visit4 are dummy variables; visit2 = 1 if at visit 2, 0 otherwise; visit3 = 1 if at visit 3, 0 otherwise; visit4 = 1 if at visit 4, 0 otherwise; group = 1 if in LGG group, 0 otherwise.