Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma

Figure 2 Case presentation of combined hepatocellular-cholangiocarcinoma. A: Preoperative computed tomography shows a large mass composed of two major components that replaces the lateral segment. The mass shows ringed enhancement in the delayed phase in the cephalad area and early enhancement with washout in the delayed phase in the caudal area. Intrahepatic metastases are observed in the S4 segment (arrow); B: Gross features of the resected specimen. Hepatocellular carcinoma (HCC) components are composed of tan-colored soft tissues. Cholangiocarcinoma (CC) components are composed of white firm tissues with central necrosis; C: Small round cells and fibrous stroma are observed at the boundary area between the HCC and CC components (blue flame in panel B).