From esophagus to colon: A narrative review of eosinophilic gastrointestinal disorders

doi:10.4291/wjgp.v17.i1.115307

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 1

This Article

(37)

(43)

(0)

(38)

(1659)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Pathophysiology

ISSN

2150-5330

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Pathophysiol. Mar 22, 2026; 17(1): 115307
Published online Mar 22, 2026. doi: 10.4291/wjgp.v17.i1.115307

Table 4 The emerging molecules in management of eosinophilic gastrointestinal disorders

Molecule	Mechanism	Development phase
Cendakimab	Anti IL-13. Reduce eotaxin-3 mediated eosinophil recruitment	Phase 2
Mepolizumab	Anti IL-5. Reduces eosinophil survival/activation	Phase 2
Benralizumab	Anti IL-5Rα. Induces near-complete eosinophil depletion	Phase 3
Tezepelumab	Anti-TSLP. Blocks epithelial “alarmin” TSLP upstream of Th2 cascade	Phase 3
Lirentelimab	Anti-Siglec-8. Depletes eosinophils and inhibits mast cells	Phase 2/3

IL: Interleukin; TSLP: Thymic stromal lymphopoietin; Th2: T helper type 2.

Full Size Table

Citation: Qasim A, Zacharia GS, Veena F, Kandhi SD, Patel H. From esophagus to colon: A narrative review of eosinophilic gastrointestinal disorders. World J Gastrointest Pathophysiol 2026; 17(1): 115307
URL: https://www.wjgnet.com/2150-5330/full/v17/i1/115307.htm
DOI: https://dx.doi.org/10.4291/wjgp.v17.i1.115307

Qasim A, Zacharia GS, Veena F, Kandhi SD, Patel H. From esophagus to colon: A narrative review of eosinophilic gastrointestinal disorders. World J Gastrointest Pathophysiol 2026; 17(1): 115307 [PMID: 41884200 DOI: 10.4291/wjgp.v17.i1.115307]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.