Gut microbiota as a potential predictor of therapeutic response in adults with Crohn’s disease: A systematic review

Table 4 Microbial taxonomic associations with response to therapy in studies using a single class of drug to treat Crohn’s disease

Microbial taxa	Park et al[64], 2022, CDAI	Guo et al[62], 2024, HBI	Dovrolis et al[60], 2020, HBI	Yilmaz et al[68], 2019, C and B	Ananthakrishnan et al[57], 2017, HBI	Doherty et al[9], 2018, CDAI
	TNF inhibitor				Integrin inhibitor	Interleukin inhibitor
Actinobacteria	P
Dorea	P
Agathobaculum	P
Blautia	P		N
Proteobacteria	N
Enterobacteriaceae	N
Odoribacter	N
Ruminococcus gnavus	N		N
Lachnoclostridium		P
Akkermansia		P
Ruminococcus		P	P
Parvimonas			P
Hungatella			P
Roseburia			P	P
Stenotrophomonas			P
Negativibacillus			N
Faecalibacterium			N			P
Eubacterium_hallii_group			N
Bifidobacterium				P
Collinsella				P
Lachnospiraceae				P
Eggerthella				P
Phascolarctobacterium				N
Bacteroides						P
Burkholderiales					P
Roseburia inulinivorans					P

P: Positive association; N: Negative association; TNF: Tumour necrosis factor; CDAI: Crohn’s disease activity index; HBI: Harvey Bradshaw index; C and B: Clinical and biochemical.