Gut microbiota as a potential predictor of therapeutic response in adults with Crohn’s disease: A systematic review

Table 2 Microbial diversity at baseline and prediction of response to therapy

Ref.	Alpha diversity1	Beta diversity1
Ananthakrishnan et al[57], 2017	Alpha diversity (Fisher’s alpha) higher in those achieving remission	Lower beta diversity in remission group (Bray Curtis dissimilarity)
Lee et al[63], 2021	Responders to anti-cytokine therapy had significantly higher indices of microbial richness at baseline	NA
Doherty et al[9], 2018	No significant difference in alpha diversity (Inverse Simpson index)	Baseline beta diversity was significantly different by response (P = 0.018)
Effenberger et al[61], 2021	No significant difference in alpha diversity (Shannon index)	No significant difference in beta diversity (paired Bray Curtis distance)
Yilmaz et al[68], 2019	No significant difference in alpha diversity	NA
Guo et al[62], 2024	No significant difference in alpha diversity (microbial richness and evenness)	NA
Dovrolis et al[60], 2020	NA	Distinct enterotype of bacteria noted in the two groups

¹Comparison between responders and non-responders to therapy.

NA: Not available.