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Publication Name
World Journal of Gastrointestinal Pathophysiology
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2150-5330
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©The Author(s) 2025.
World J Gastrointest Pathophysiol. Dec 22, 2025; 16(4): 111550
Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111550
Figure 1
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Figure 1 Pancreatic enzyme autodigestion and immunocyte-mediated inflammation. Molecular mechanisms involved in pancreatitis. In normal conditions, pancreatic enzymes aid digestion. However, during pancreatitis, inappropriate activation of trypsinogen leads to autodigestion within the pancreas, causing inflammation. This triggers the secretion of chemokines and other cytokines, which attract and activate immune cells, further amplifying the inflammatory response and exacerbating pancreatic damage.
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