Update on the pathogenesis and clinical management of Helicobacter pylori gastric infection and associated diseases

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Dec 22, 2025; 16(4): 111432
Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111432

Table 2 Helicobacter pylori vaccines currently in clinical trials - clinicalTrials.gov database

Vaccine classification	Intervention/treatment	ClinicalTrials.gov ID	Phase	Status	Sponsor
Therapeutic vaccines	Biological: CTA control/biological: IMX101 vaccine	NCT03270800	1	Completed	ImevaX
Prophylactic vaccines	Biological: H. pylori vacines/biological: Placebo Vaccine	NCT00736476	1	Completed	Novartis Vaccines
	Biological: H. pylori vaccine/biological: Placebo	NCT02302170	3	Completed	Jiangsu Province Centers for Disease Control and Prevention
	Biological: H. pylori vaccine/biological: Placebo	NCT00613665	1	Completed	Novartis Vaccines

H. pylori: Helicobacter pylori.

Citation: Costa JMC, Aguiar CEO, Oliveira MMGL, Cenci Dietrich V, Lima PHM, Freire JPC, Lemos FFB, Queiroz DMM, de Melo FF. Update on the pathogenesis and clinical management of Helicobacter pylori gastric infection and associated diseases. World J Gastrointest Pathophysiol 2025; 16(4): 111432
URL: https://www.wjgnet.com/2150-5330/full/v16/i4/111432.htm
DOI: https://dx.doi.org/10.4291/wjgp.v16.i4.111432

Costa JMC, Aguiar CEO, Oliveira MMGL, Cenci Dietrich V, Lima PHM, Freire JPC, Lemos FFB, Queiroz DMM, de Melo FF. Update on the pathogenesis and clinical management of Helicobacter pylori gastric infection and associated diseases. World J Gastrointest Pathophysiol 2025; 16(4): 111432 [PMID: 41479869 DOI: 10.4291/wjgp.v16.i4.111432]

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