Drug-induced liver injury from high-dose intravenous methylprednisolone: A rare but known adverse effect

Table 2 Naranjo adverse drug reaction probability scale for the patient

Question	Yes	No	Do not know	Score
Are there previous conclusive reports on this reaction?	+ 1	0	0	+ 1
Did the adverse event appear after the suspected drug was administered?	+ 2	- 1	0	+ 2
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?	+ 1	0	0	+ 1
Did the adverse reaction reappear when the drug was readministered?	+ 2	- 1	0	0
Are there alternative causes (other than the drug) that could on their own have caused the reaction?	- 1	+ 2	0	+ 2
Did the reaction reappear when a placebo was given?	- 1	+ 1	0	0
Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?	+ 1	0	0	0
Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	+ 1	0	0	0
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+ 1	0	0	0
Was the adverse event confirmed by any objective evidence?	+ 1	0	0	+ 1
Total score				7